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Isaac wears a pink bow or ribbon on his head.
Everytime Isaac takes any form of damage (from enemies, self-damage items, bombs or even blood donation machines), there is a chance he will gain a temporary shield that nullifies all damage while it is active, similar to Celtic Cross (although with higher possibility).
The activation chance depends on the Luck stat, and goes up to 100% with 10 Luck.
Turn all negative pills into their positive counterparts like how PHD does: Stat-down pills will turn into stat-up pills, Amnesia into I Can See Forever, Bad Trip into Balls of Steel. Different from PHD, Virgo can't enable you to identify unknown pills.
- Mom's Bottle Of Pills - Pills generated will be much more beneficial. If many types of stat-up or stat-down pills appear in this playthrough, the player can get very high amount of attributes.
- IV Bag, Blood Donation Machine and Devil Beggar - When the shield is activited Isaac will not take any damage from these sources, enabling donating blood to them for more times.
- Blood Rights and Razor Blade - Similar to above, enabling players to use these items for multiple times.
- Sharp Plug - Sharp Plug can't be used if the player cannot take damage.