i had sacred heart,polyphemus,smb super fan,halo,relic,meat,panties,heels,lipstick,number one,guppy's head/paw/tail,skeleton key,and lard by the depths part 1.
i had sacred heart,polyphemus,smb super fan,halo,relic,meat,panties,heels,lipstick,number one,guppy's head/paw/tail,skeleton key,and lard by the depths part 1.
the best attack combo i had was the brimstone + polyphemus + max's head with cain + a few items i dont remember (some of them might be dmg ups)... it took a hell of a time to load, but it was powerful enough to kill regular bosses with one hit
I did Soul of Night + Mutant Spider + The Pact + The Small Rock.
Killed isaac, nearly killed ???.
D6 for best item.
I recently got an incredible run with Polyphemus, Brimstone, maximum HP, full damage, rainbow baby, full fly/meat halo, the relic, mitre, and a couple of other things. Basically, I took down ??? with around three shots.
Epic Fetus + Spirit of the Night (or any flight). Aimable missiles w/ the power and blast radius of mega bombs. Absolutely destroys any level or boss including the Chest & ???. Plus lets you get every item including secret & super secret rooms. A close second was Dr. Fetus + Mr. Mega + Spirit of the Night. Infinite Mega Bombs & flight. :D
My best run was when I unlocked the D6, I was using blue baby whining about how it sucks (Because it does) and got decent stuff on it, I beat moms heart but I got the first chance I ever got to go to cathedral Guess what I got there? Epic Fetus. I beat Isaac and I was like "HOLY SHIZZLE I BEAT ISAAC /W BLUE BABY!!"
D20+Habit+slot machines (through D20-acquired cards or in a casino): get started on a cycle of loot that only stops when you get tired of it or the game's memory explodes. It's so powerful but time-consuming it's depressing. I really hope they fix both the Habit and slot machines in Rebirth.
As Magdeline i got:
1: Technology,
2: Polyphemus,
3: Angel Room, Dead Dove,
4-?: Nothing but Damage Up Items & Health Up Items.
Easiest Run I've ever had.
A lot of the builds above are fun but if you haven't finished the game yet (beaten ??? in the chest) then I found I got a lot better by following some simple rules:
-Don't pick up special items you dont need (http://bindingofisaac.wikia.com/wiki/Stats and check out special) unless you are trying to reduce the specials coming up in the devil room so you can get brim or knife.
-Try and make guppy whenever you can, the flies are overpowered.
-Try and make devil rooms appear as often as possible, book of revs and pentagram is good for this. Make sure to resart the game before every run otherwise devil rooms wont appear as often. If you take red heart damage in a boss fight you are pretty much not going to get a devil deal on that floor.
My favourite is:
3/4 of the cat items (tail, dead, paw and head); Mutant Spider; Sacred heart; any other damage items and the Mitre is great cause when you get down to 0 hearts you can get your polaroid proc off every hit.
Happy Mom killing!
Tech and Tech 2, Pentagram, Coathanger, Sad Onion, PHD, Oujia Board, Meat, Meat Cube lv3, Holy Grail, Halo and The Dice
Hmm... I think I got Spirit Of The Night (def my favorite), Mutant Spider, Mr. Mega, piercing shots, Dead Cat, and Brim. Of course, this left me with one red heart... on a 7 Years Bad Luck challenge. I got it done, sure, but I had one life left by the end of it.