The Binding of Isaac Wiki

The Virus

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A syringe with a red substance in it.


Isaac becomes pale with signs of sickness on his body, and gets bumps and markings.

Touching enemies will inflict them with poison, as well as deal a large amount of damage.

The Virus also decreases Speed by 0.1, however this reduction in speed does not stack with the speed down from Odd Mushroom (Large).



  • Book Of Shadows - Turns you invincible with the poison touch effect still working while invincible.
  • The Polaroid - While invincible, allows Isaac to poison enemies without taking damage.
  • Celtic Cross - If invincibility triggers, poison touch will be effective against many enemies.
  • My Little Unicorn/The Gamekid - Poison touch overrides their 40 damage hit with its 30 damage hit (and poison). Otherwise it doesn't change what they do.
  • The Nail - The contact damage of The Virus overrides the contact damage of The Nail.
  • Mom's Bra/Mom's Pad - Contact damage on the player is disabled during the effect of either active. This allowing for safer application of the contact damage and poison damage of The Virus.
  • Best Friend - The brief window of invincibility frames when casting Best Friend allow for a free application of The Virus.



  • The substance in the syringe is probably infected blood, which is an incredibly easy way to contract STDs.
  • Lust is a recolor of Isaac with The Virus graphic applied. Lust also has a chance to drop The Virus upon death.
    • This may be why it's thought to be an STD.


  • The Virus, like all other contact damage items, cannot inflict contact damage or poison damage to Hearts or Mom's Heart/It Lives, but can do so to other enemies that don't deal contact damage to the player.

Related AchievementsEdit

"The Common Cold" - Collect two of the following items in one playthrough: Roid Rage, The Virus, or Growth Hormones.

Start a Discussion Discussions about The Virus

  • Disambiguation for similar looking items

    14 messages
    • To all the people who think brimstone is a bad item, pick it and polyphemus up in the same run, you win, no question about it, you just freak...
    • @Narius Yes, but combined with Sacred heart... I've only seen that once before, and it 1 shotted mom and Gurdy, who are 2 tanky bosses.

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