A syringe with a red substance in it.
Isaac becomes pale with signs of sickness on his body, and gets bumps and markings.
Touching enemies will inflict them with poison, as well as deal a large amount of damage.
- Book Of Shadows - Turns you invincible with the poison touch effect still working while invincible.
- The Polaroid - While invincible, allows Isaac to poison enemies without taking damage.
- Celtic Cross - If invincibility triggers, poison touch will be effective against many enemies.
- My Little Unicorn/The Gamekid - Poison touch with the active effect.
- The substance in the syringe is probably infected blood, which is an incredibly easy way to contract STDs.
- Lust is a recolor of Isaac with The Virus graphic applied.
- This may be why it's thought to be an STD.