And that no man might buy or sell, save he that had the mark, or the name of the beast, or the number of his name.

–Revelation 13:17

A red marking of three 6s (The number of the beast, 666) making a triangle.


  • Isaac gets a mark on his forehead.
  • Increases Damage by 1 and Speed by 0.2. Adds one Soul Heart.
  • Will kill you if you have two or fewer Heart Containers from a deal with the devil despite giving you one Soul Heart; if it costs 2 health and you have 2 health you will die. If you have 1 health and it costs 2 health you will die.





  • From the Book of Revelation: "And I saw thrones, and they sat upon them, and judgment was given unto them: and I saw the souls of them that were beheaded for the witness of Jesus, and for the word of God, and which had not worshipped the beast, neither his image, neither had received his MARK upon their foreheads, or in their hands; and they lived and reigned with Christ a thousand years." (quote 20:4).
  • The pickup shows the tips of the sixes meeting in the middle, however when the player recieves the mark the bodies of the sixes are touching with the tails facing outward
  • The mark may be a reference to the British classic "The Omen" where a possessed child has a mark of three sixes hidden under his hair on his forehead. 


Start a Discussion Discussions about The Mark

  • Cain and the Mark

    2 messages
    • Got the Mark with Cain, alongside Brimstone. I had 3 hearts, 3 soul hearts, yet all of my health died. Was  killed in one shot from a fly. Wh...
    • When i was playing with samson i had 1 normal heart and 5 soul hearts...for the mark i needed 2 normal hearts, when i took it, it took ALL of...
  • Blue baby and The Mark

    4 messages
    • Yup, got it. But the cost was three spirit hearts and i had those three spirit hearts. And btw on the death screen it showed that i had one spi...
    • Yes, this is not a bug. When you make the deals with the devil, you first pay for your health, then get the deal. Situation: You had 3 hear...

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.