This boss moves at a much faster rate than The Duke of Flies. He mainly uses the spawning of Flies, like the original Duke of Flies, as well as that of Spiders to attack. He also spits out blood projectiles, one similar to Monstro's cough attack (though with fewer projectiles), and the other similar to Loki's 8-way blood shot. Like his predecessor, The Husk has comparably little health and can go down within a few seconds. Also, his attacks are random, so these are a few warning signs that should be looked out for:
- When he grins, he vomits blood (similar to Monstro).
- When he puffs up, he will fire the 8-way blood shot.
The Spiders are more threatening than the Flies, so they should be taken out first. If you remember these signs, you will escape with little to no harm. Remember - patience is the key
Spawns flies and Boom Flies. Also periodically shoots 8 directional bullets. When killed, leaves several flies and two Boom Flies.
Roughly half as big (picture here is not actual size) and moves at double speed. Does not spawn enemies at all, but fires bullets constantly in 8 directions. When killed, leaves several flies and two Red Boom Flies.
- The Husk was called "Duke of Flies 2" during development.
- When killed by The Husk, the Duke Of Flies will appear on Isaac's Last Will.
- His left eye appears to be partially open and missing, but both of Duke of Flies's eyes seem to be pushed in.
|Basement||Larry Jr. • Monstro • The Duke of Flies • Gemini • Steven • Famine|
|Cellar||Widow • Pin • The Duke of Flies • Famine • Gurdy Jr. • The Blighted Ovum|
|The Caves||Fistula • Peep • Gurdy • Chub • C.H.A.D. • Pestilence|
|Catacombs||The Husk • The Hollow • The Blighted Ovum • The Carrion Queen • Peep • Pestilence • The Wretched • Gurdy Jr.|
|The Depths||Loki • Monstro II • Gish • War • Mom|
|Necropolis||Mask of Infamy • Daddy Long Legs • The Carrion Queen • The Bloat • Loki • War • The Wretched • Mom|
|The Womb||Scolex • Blastocyst • The Bloat • Death • Conquest • Daddy Long Legs • Triachnid • Teratoma • Mom's Heart • It Lives|
|Utero||Teratoma • The Bloat • Death • Conquest • Daddy Long Legs • Triachnid • Lokii • Mom's Heart • It Lives|
|Sheol||The Fallen • Satan|
|First to fifth and seventh level||The Fallen • Headless Horseman|