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- Blue Womb: A new area, featuring a new ending and final boss.
- Daily Runs: Daily seeded runs with online leaderboards.
- Two new characters, Lilith and Keeper.
- 10 new challenges.
- 4 new alternate chapters: Burning Basement, Flooded Caves, Dank Depths, and Scarred Womb.
- Many new room layouts including tiny rooms, long hallways, and L-shaped rooms.
- New room types like trap rooms, double treasure rooms, and closets.
- New special seeds, along with a seed code combo page.
- An expanded soundtrack.
- An extra HUD option, allowing items picked up to be displayed on-screen.
- 9 new transformations.
- New bosses, along with new variations of bosses introduced in Rebirth.
- New monsters.
- Updated item combo system.
- New achievements.
- New co-op babies.
- An improved collection page that shows item descriptions.
|Main Series|| The Binding of Isaac (Wrath of the Lamb • Eternal Edition)|
Rebirth (Afterbirth • Afterbirth †)
|Spin-offs||The Legend of Bum-bo|
|Miscellaneous||TBoI DEMO • TBoI: Unholy Edition • Updates|