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Offical artwork by Edmund McMillen

The Womb
Catacombs (Rebirth)
Necropolis (Rebirth)

Related Boss(es):
Super Envy


  • Contact damage
  • First part splits into 3 medium parts when damaged enough
    • Medium parts split into 2 smaller parts.
    • Smaller parts spawn Spiders after death

Effective item(s):
Spider's Bite
Mom's Contacts


Teratoma is a boss that can be encountered in Wrath of the Lamb. It resembles a posthumous version of Fistula.


It acts like Fistula, but spawns 3 medium sections instead of 4. Teratoma also spawns small Spiders when the smallest part of it is destroyed. It is a boss in The Womb I and Utero I . In The Binding of Isaac: Rebirth, any room layout in the Catacombs and Necropolis that should contain Fistulas in WotL now contain Teratomas.

  • Be careful to not split off too many parts at once. This could impair your ability to dodge.
  • Anything that damages multiple enemies will help you speed up the battle (especially when a larger amount of sections are present on the screen)

Gallery Edit

Trivia Edit

  • In biology, a teratoma is a tumor like growth that contains normal tissue from each of three germ layers (like hair, teeth or even bones). Like Fistula, these medical facts reference to their appearance (note the bones around Teratoma).


The Binding Of Isaac- Teratoma Bossfight00:34

The Binding Of Isaac- Teratoma Bossfight

Teratoma Bossfight

Basement Larry Jr.MonstroThe Duke of FliesGeminiStevenFamine
Cellar WidowPinThe Duke of FliesFamineGurdy Jr.The Blighted Ovum
The Caves FistulaPeepGurdyChubC.H.A.D.Pestilence
Catacombs The HuskThe HollowThe Blighted OvumThe Carrion QueenPeepPestilenceThe WretchedGurdy Jr.
The Depths LokiMonstro IIGishWarMom
Necropolis Mask of InfamyDaddy Long LegsThe Carrion QueenThe BloatLokiWarThe WretchedMom
The Womb ScolexBlastocystThe BloatDeathConquestDaddy Long LegsTriachnidTeratomaMom's HeartIt Lives
Utero TeratomaThe BloatDeathConquestDaddy Long LegsTriachnidLokiiMom's HeartIt Lives
Sheol The FallenSatan
Cathedral Isaac
The Chest ???
First to fifth and seventh level The FallenHeadless Horseman
Devil Room Krampus

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