No curses before Everything's TerribleEdit
Reset my stats recently and I haven't seen any curses yet. Up to ending 4 and haven't attempted completed any challenges yet. Helston 12:58, June 26, 2012 (UTC)
Cursed after beating Mom's Heart Edit
I had "Curse of the Labyrinth" on my first playthrough after defeating Mom's Heart for the first time. No curses before.