|Spirit Of The Night|
Isaac's head becomes black, with large teeth and white eyes, and his lower body is replaced by a black ghost-like appendage.
- This item's name, and Isaac's appearance upon picking it up, is a direct reference to the Magic: The Gathering card of the same name.
- Another Devil Room item that grants flight, Lord of the Pit, is also a reference to a Magic: The Gathering card.
- The effects of the item may also be tied to the original card. Both Isaac and the card fly, and the card can damage players even if they defend themselves, similar to Isaac's ability to shoot through obstacles.
- This item is the Devil Room counterpart of the Dead Dove.
- This item's sprite is identical to the Wiccan moon-symbol of blessing.
- While playing as ??? the eyes appearance still white circles but with the cross (x) of ???'s eyes appearance.