Sissy Longlegs is a familiar introduced in The Binding of Isaac Rebirth. She is a blue longlegs spider.


Her expression turns vacant when she is acquired.

She scuttles around with Isaac in rooms, sometimes spawning friendly blue spiders that damage enemies. She can only spawn one living spider at any given time.
Sissy Longlegs loves you

Sissy Longlegs spawning a friendly spider to assist.

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