A red heart with a small fire on the top, and a cross on the front of it in a lighter shade of red.
- Isaac's eyes glow white, and white, glowing tears stream down his face.
- Shots are larger, travel slower, have a slower Fire Rate, and home in on enemies.
- Damage is multiplied. Decreases Tears by 1.
- Gives 1 Soul Heart upon pickup.
- All bombs also home in on enemies, including those created by Dr. Fetus.
- Technology - Turns laser purple and increases damage.
- Stacks with Polyphemus.
- Stacks with Mutant Spider.
- The Parasite - When the tear breaks into 2 tears, those tears will also home in on enemies.
- IPECAC - Slows down the shot, and allows them to home on enemies.
- Dr Fetus: Bomb turns white and homes in on enemies.
- The item is based off of the Sacred Heart of Jesus, as seen in many paintings with him as a burning heart encircled with thorns.