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- Isaac 'becomes' Meat Boy, gaining his signature teeth, grin, bandage and black eye, along with his skin looking red.
- +1 Heart container.
- +0.2 Tears.
- +0.3 Damage.
- +0.2 Speed.
- +0.5 Range
- +0.1 Shot height.
- Meat Boy is the eponymous main character of Super Meat Boy, another game created by Edmund McMillen.
- The icon for this item is based on the saw blades from Super Meat Boy.
- Edmund McMillen later revealed that the speed down stat was actually supposed to be a speed up stat. This was fixed in the Eternal update.
- From the original game, Isaac's tears will become red and leaves behind a cosmetic trail of blood wherever he goes. It wasn't displayed in Rebirth, however.