A syringe with a green substance inside.


Isaac appears aggressive and angry.

Although the pickup quote claims that the item increases both speed and range, the item only increases Speed by 0.6.



  • Flight - Being able to fly will allow much easier control of Isaac due to his high speed.



  • This item's name, appearence and effect are taken from an item from The C Word, another of Edmund McMillen's games.
  • Roid Rage is a term for aggressive behavior caused by the abuse of steroids.

Related Achievements

"The Common Cold" - Collect two of the following items in one playthrough: Roid Rage, The Virus, or Growth Hormones.

Start a Discussion Discussions about Roid Rage

  • Disambiguation for similar looking items

    14 messages
    • To all the people who think brimstone is a bad item, pick it and polyphemus up in the same run, you win, no question about it, you just freak...
    • @Narius Yes, but combined with Sacred heart... I've only seen that once before, and it 1 shotted mom and Gurdy, who are 2 tanky bosses.

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