Similarly to Fireplaces, it can be destroyed with tears and will infrequently drop Heart and Coin Pick Ups, although more commonly than Fireplaces. However, destroying Poop or Fireplaces with any type of explosive (Bombs, IPECAC, Epic Fetus, etc.) will not result in a Pick Up dropping, with the exception of Golden Poop.
Poop is most often encountered in its basic form. However, three additional types of Poop are encountered in the Wrath of the Lamb.
It more frequently drops coins than hearts. As usual, these items can drop in any variety, so poop might drop a nickel or even a dime instead of a coin; or half a heart, a soul heart or even an eternal heart instead of a full heart.
Poop has a small chance to spawn as Corny Poop instead.
An Eternal Fly circles around the poop, and it is invulnerable to damage until the poop is destroyed. It then turns into an Attack Fly with increased health and size. The Eternal Fly can damage the player while it circles the poop if the player stands in the Eternal Fly's path.
Another alternate form of poop, and very rare. Golden Poop is also very durable, it takes more hits to destroy than normal poop. Drops 5-8 coins (2/3 chance) or the Counterfeit Penny Trinket (1/3 chance, assuming it is unlocked). Golden Poop will usually replace corny poop if left untouched, but can also replace normal poop. Corny Poop has a very slim chance to turn into Golden Poop (if left untouched) when the player enters and re enters the room.
This type of poop is only naturally found in certain rooms in The Chest, and dropped by The Carrion Queen, who excretes them. This poop will damage Isaac for a half heart (a full heart in The Womb and onwards), indicated by a burning sound. It cannot be permanently destroyed, and will respawn after a few seconds.
- Corny Poop: Once the room is entered, the poop type is permanently determined. So after re-entering a room, Corny Poop and regular Poop will still be on the same spots. (With the exception of Golden Poop, see next note).
- Golden Poop: Whether Golden Poop appears it decided each time you enter a room - once you leave and re-enter the same room, it will usually be gone.
- Red Poop: It never replaces any other type of poop and only spawns in predetermined spots.
- Since it takes little time and no resources, destroying poop is generally worth the effort and can sometimes increase the amount of money substantially. More often than not, it can decide between having enough money for the shop on an early level or not.
- Due to the spawn behavior of Golden Poop, a way for getting coins is to carefully leave and re-enter a room with Corny Poop in it repeatedly until one turns into the Golden Poop.
- The Bean is unlocked by destroying 50 poops.
- Larry Jr. can emit poop, although its Blue Champion version does not.
- If Larry Jr. poops on top of a pre-existent poop, and then the player leaves the room (via teleport, or simply beating the boss) and re-enters, the poop will be seen, but it can be walked over and can not be destroyed.
- Edmund McMillen confirmed that red poop causes damage "because it is made out of AIDS" in regards to the Carrion Queen.
- When a pile of Poop is destroyed, a "smile" can be seen.