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Nerve Ending

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Isaac Rebirth

Nerve Ending is a bizarre static enemy appearing in The Binding of Isaac: Rebirth. It essentially acts as a meat shield, and very rarely will shoot a single blood bullet.


They're completely weak, but they still can deal damage to the character if contacted. It often spawns with an "eye."


  • This enemy may be a reference to the episode "Ren's Toothache" from the classic Nickelodeon cartoon The Ren & Stimpy Show.
Normal monsters
I Blob-button

I. Blob
More monsters coming soon...
Flies Black FlyAttack FlyMoterEternal FlyPooterFat FlyBoom FlyRed Boom FlyDrowned Boom FlySuckerSpitDart FlySwarm FlyRing FlyLevel 2 FlyFull FlyHush FlyBall of Flies
Spiders SpiderBig SpiderTriteRaglingRag TriteLevel 2 SpiderTicking SpiderBaby Long LegsCrazy Long LegsWall CreepBlind CreepRage Creep
Spheres BoilGutSackBlue BoilWalking Variants
Mulligans MulliganMulligoonMulliboomHiveSwarmerNestDrowned Hive
Headless HopperFlaming HopperLeaperPacerGusherSplasher
Gapers GaperFrowning GaperGurgleMr. MawFlaming GaperCyclopiaSkinnyRottyNullGreed GaperBlue GaperSwinger
Heads HorfPsychic HorfMawRed MawPsychic Maw
Globins GlobinGazing GlobinBlack GlobinDank Globin
Knights KnightSelfless KnightFloating KnightBone Knight
Blobs ClottyClotMega Clotty
Maggots MaggotChargerSpittyConjoined SpittyDrowned ChargerGrub
Body parts Mask + HeartBrainMemBrainGutsMama GutsEyeBloodshot EyeMom's HandDead Mom's HandScarred GutsNerve EndingStone Eye
Worms Para-BiteCod WormScarred Para-BiteRound WormNightcrawlerRoundyUlcer
Leeches LeechKamikaze LeechHoly Leech
Poop DipCorn DipBrown DipSquirtDank SquirtDinga
Skeletons BonyBlack BonyDeath's HeadDank Death's HeadFlesh Death's Head
Ghosts Lil' HauntWizoobRed Ghost
Bats One ToothFat Bat
Fatties FattyFlaming FattyConjoined FattyBlue Conjoined FattyPale Fatty
Hosts HostRed HostWalking HostWalking Red Host
Vises VisDouble VisChubberCage VisScarred Double Vis
Tumors TumorPsy TumorCamillo Jr.
Spikes Wall HuggerSlidePoky
Babies BabyAngelic BabyEmbryoImp
Homunculuses HomunculusBegotten
Keepers KeeperHanger
Grimaces Stone GrimaceVomit GrimaceGaping MawTurret GrimaceBrimstone Grimace
Oobs OobBlack Maw
Others FredLumpB. LickerDukieDopleEvil TwinMeatball

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