The Binding of Isaac Wiki

Monster Manuel

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IsaacHDXxx form2Isaac Rebirth

Monster Manual is an item in The Binding of Isaac and the Rebirth remake. It is a book with a centaur, horse, and a dragon on its cover.


Upon activation, Satan's laugh will be heard and a random Familiar (even locked familiars) will spawn and help Isaac for the current room. Can spawn one of the following:

In Rebirth, any familiar can spawn.


  • Combined with items such as the 9 Volt, Habit, etc. can allow Isaac to have an army of familiars following him. Using this in a boss room can cause the boss to lose health very rapidly.


  • The item and its graphics are both references to the D&D Monster Manual.
  • Its presence is related to the statement that D&D is a gateway to Satanism.
  • The secret pop-up for this item misspells "Monster Manual" as "Monster Manuel".


  • More than 3 orbitals may be active as a result using this item; this may have been done to avoid deleting old orbitals by accident, or could have been simply overlooked.
  • Will spawn "undefined," if too many familiars are present on screen.  

Related Achievements

TheMonsterManual "The Monster Manual" - Complete Sheol with Judas.

Passive Items
Cricket's Body
Cricket's Head
Guppy's Collar
Isaac's Heart
Roid Rage
Activate Items
Bob's Rotten Head
Book Of Revelations
Dead Sea Scrolls
Guppy's Head
Mega Blast
Monster Manuel
Tammy's Head
The Bible
The Book of Belial
Yum Heart
Bob's Brain
Dark Bum
Health Items
Breakfast Lunch A Snack Dinner Dessert

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