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Monster Manuel

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IsaacHDXxx form2Isaac Rebirth

Monster Manual is an item in The Binding of Isaac and the Rebirth remake. It is a book with a centaur, horse, and a dragon on its cover.


Upon activation, Satan's laugh will be heard and a random Familiar (even locked familiars) will spawn and help Isaac for the current room. Can spawn one of the following:

In Rebirth, any familiar can spawn.


  • Combined with items such as the 9 Volt, Habit, etc. can allow Isaac to have an army of familiars following him. Using this in a boss room can cause the boss to lose health very rapidly.


  • The item and its graphics are both references to the D&D Monster Manual.
  • Its presence is related to the statement that D&D is a gateway to Satanism.
  • The secret pop-up for this item misspells "Monster Manual" as "Monster Manuel".


  • More than 3 orbitals may be active as a result using this item; this may have been done to avoid deleting old orbitals by accident, or could have been simply overlooked.
  • Will spawn "undefined," if too many familiars are present on screen.  

Related Achievements

TheMonsterManual "The Monster Manual" - Complete Sheol with Judas.

Passive Items
<320/203 Dollar Bill8 Inch Nails9 VoltAbaddonAnemicAnkhAnti-GravityAquariusAriesAthameBall of TarThe BatteryThe BeltBest Friends ForeverBetrayalBinkyThe Black BeanBlack CandleBlack LotusBlack PowderBlood BagBlood ClotBlood Of The MartyrBloody LustBlue CapBlue MapBobby-BombBob's CurseThe BodyBogo BombsBomber BoyBoom!BoxBrimstoneBucket Of LardBursting SackButt BombsCaffeine PillCain's Other EyeCambion ConceptionCapricornCar BatteryCat-O-Nine-TailsCeltic CrossCenserCeremonial RobesChampion BeltChaosCharm Of The VampireChemical PeelChocolate MilkCircle of ProtectionThe Common ColdThe CompassContinuumContract From BelowCrack JacksCricket's BodyCricket's HeadCrown Of LifeCupid's ArrowCursed EyeCurse of the TowerDaddy LonglegsDark MatterDead DoveDead EyeDead OnionDeath's TouchDeep PocketsA DollarDr. FetusE ColiEden's BlessingsEmpty VesselEpic FetusEpiphoraEve's MascaraEvil EyeExperimental TreatmentExplosivoFanny PackFateFruit CakeGB BugGimpyGlitter BombsGnawed LeafGodheadGod's FleshGoat HeadGrowth HormonesGuillotineGuppy's CollarGuppy's TailHabitThe HaloHead Of The KeeperHive MindHoly GrailHoly Light!Holy MantleHoly WaterHot BombsHumbling BundleImmaculate ConceptionInfamyInfestationInfestation 2The Inner EyeIPECACIron BarIsaac's HeartJesus JuiceJudas' ShadowJuicy SackKidney StoneThe LadderLatch KeyLazarus' RagsLeoLibraLittle BaggyLoki's HornsLord Of The PitLost ContactLucky FootThe Ludovico TechniqueA Lump of CoalLusty BloodMaggy's BowMagic 8 BallMagic MushroomMagic ScabMagnetoThe MarkMarkedMatch BookMaw of the VoidMEAT!Midas' TouchThe MindMini MushMissing Page 2Missing No.MitreMom's Coin PurseMom's ContactsMom's EyeMom's EyeshadowMom's HeelsMom's KeyMom's KnifeMom's LipstickMom's PearlsMom's PerfumeMom's PurseMom's UnderwearMom's WigMoney = PowerMonstro's LungMore OptionsMr. DollyMr. MegaThe MulliganMutant SpiderMysterious LiquidMy ReflectionMy ShadowNight LightNo. 2Number OneOdd Mushroom (Large)Odd Mushroom (Thin)Old BandageOuija BoardThe PactPageant BoyThe ParasitePay To PlayPentagramPHDPiggy BankPiscesPlacentaProptosisPupula DuplexPurityPyromaniacA QuarterRaw LiverRestockRoid RageRosaryRubber CementSack HeadSacred HeartSad BombsThe Sad OnionSafety PinSagittariusSamson's ChainsScapularScatter BombsScorpioScrewSerpent's KissSharp PlugSkatoleSkeleton KeyThe Small RockSMB Super Fan!Soy MilkThe SoulSpear of DestinySpeed BallSpelunker HatSpider BabySpider's BiteSpirit Of The NightSpoon BenderSqueezyStarter DeckSteam SaleStem CellsStevenSticky BombsStigmataStop WatchStrange AttractorSuper BandageSynthoilTaurusTech XTechnologyTechnology 2Technology .5The NegativeThe PolariodThere's OptionsThunder ThighsTiny PlanetTooth PicksTough LoveToxic ShockTractor BeamTranscendenceTreasure MapTrinity ShieldVirgoThe VirusThe WaferWhore Of BabylonWire Coat Hanger!The WizWooden SpoonXRay VisionZodiac
Activated Items
Anarchist CookbookThe BeanBest FriendThe BibleBlank CardBlood RightsBob's Rotten HeadThe Book of BelialBook Of RevelationsBook of SecretsBook of ShadowsThe Book Of SinThe BoomerangeBox of FriendsBox of SpidersBreath Of LifeButter BeanThe CandleConverterCrack The SkyCrystal BallD7D8D10D12D100D20D4Dad's KeyDead Sea ScrollsDeck Of CardsThe DiceDiplopiaDoctor's RemoteFlush!Forget Me NowFriendly BallThe GamekidGlass CannonGlowing Hour GlassGuppy's HeadGuppy's PawHead of KrampusThe HourglassHow To JumpIsaac's TearsIV BagThe JarJar of FliesKamikaze!Kidney BeanLemon MishapMagic FingersMega BeanMega BlastMine CrafterMom's Bottle of PillsMom's BoxMom's BraMom's PadMonster ManualMr. BoomMy Little UnicornThe NailThe NecronomiconNotched AxePandora's BoxThe Pinking ShearsPlaceboThe PoopPortable SlotPolyphemusPrayer CardRazor BladeRed CandleRemote DetonatorSatanic BibleShoop Da Whoop!ScissorsSpider ButtTammy's HeadTear DetonatorTeleport!Teleport 2.0Telepathy For DummiesUndefinedUnicorn StumpVentricle RazorWhite PonyWooden NickelYum Heart
???'s Only Friend1UPAbelBall of BandagesBest BudBig ChubbyBig FanBob's BrainBomb BagBrother BobbyBumboBum FriendCharged BabyCube of MeatDark BumDead BirdDead CatDistant AdmirationDemon BabyFarting BabyFate's RewardFinger!Forever AloneFriend ZoneGeminiGhost BabyGuardian AngelGuppy's Hair BallHalo of FliesHarlequin BabyHeadless BabyHost HatIncubusKey BumKey Piece 1Key Piece 2Lil' BrimstoneLil' ChestLil GurdyLil' LokiLittle C.H.A.D.Little ChubbyLittle GishLittle SteveLost FlyMilk!Mongo BabyMultidimensional BabyMystery SackObsessed FanPapa FlyThe PeeperPunching BagRainbow BabyThe RelicRobo-BabyRobo-Baby 2.0Rotten BabyRune BagSack Of PenniesSacrificial DaggerSeraphimSissy LonglegsSister MaggySmart FlySpider ModSuccubusSworn Protector
Health Items
A SnackBreakfastDessertDinnerLunch
TBoI-only items
Max's HeadWiggle Worm

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