- Isaac gains red, messy lipstick marks around his mouth.
- +5.25 Range.
- +0.5 Shot height.
- From the The Binding of Isaac: Afterbirth expansion for Rebirth, it becomes an item related to the Yes Mother transformation.
- From the original game, along with other items, Mom's Lipstick's pickup quote has an exclamation point at the end.
- From the original game, the range stats for the item is +7.75.