The MemBrain is a much larger Brain which can be rarely encountered in The Depths and more commonly in The Womb, Utero, and The Chest. They appear in The Binding of Isaac as well as the Rebirth remake.
It has a large amount of health, and will split into 2 Brains upon death.
Unlike regular Brains, it leaves no red Creep behind and moves very slowly. Its primary form of attack is to jump and shoot eight big red shots in all eight directions upon landing on the floor. The same attack is used by Mama Guts.
- MemBrain is a portmanteau from the words Membrane and Brain: It is the separating layer of 2 Brains.