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Homunculuses are deformed, child-like monsters that can only appear in Chapter 4 commonly.


They're usually attached to walls with "umbilical cords". Homunculuses can be seen sleeping at first, but as soon as entering the room where the creatures located, their eyes will open and heads start shaking. Afterwards, they'll try and run to Isaac.

Given enough time, it will detach from the wall, shooting 6 blood shots, and chase after Isaac quickly. They'll leave a small amount of red creep after death if either still attached to the wall or detached.


  • They will still leave creep behind when using the D10 item.
  • Using the "Death" tarot card will prevent them from leaving a trail of red creep after being killed.
  • 4 Homunculuses always appear during the Mr. Fred boss fight. Not free at all, but they can be only detach by Mr. Fred's command.


  • A homunculus is a small human-like creature from sixteenth century folktales.
Normal monsters
I Blob-button

I. Blob
More monsters coming soon...
Flies Black FlyAttack FlyMoterEternal FlyPooterFat FlyBoom FlyRed Boom FlyDrowned Boom FlySuckerSpitDart FlySwarm FlyRing FlyLevel 2 FlyFull FlyHush FlyBall of Flies
Spiders SpiderBig SpiderTriteRaglingRag TriteLevel 2 SpiderTicking SpiderBaby Long LegsCrazy Long LegsWall CreepBlind CreepRage Creep
Spheres BoilGutSackBlue BoilWalking Variants
Mulligans MulliganMulligoonMulliboomHiveSwarmerNestDrowned Hive
Headless HopperFlaming HopperLeaperPacerGusherSplasher
Gapers GaperFrowning GaperGurgleMr. MawFlaming GaperCyclopiaSkinnyRottyNullGreed GaperBlue GaperSwinger
Heads HorfPsychic HorfMawRed MawPsychic Maw
Globins GlobinGazing GlobinBlack GlobinDank Globin
Knights KnightSelfless KnightFloating KnightBone Knight
Blobs ClottyClotMega Clotty
Maggots MaggotChargerSpittyConjoined SpittyDrowned ChargerGrub
Body parts Mask + HeartBrainMemBrainGutsMama GutsEyeBloodshot EyeMom's HandDead Mom's HandScarred GutsNerve EndingStone Eye
Worms Para-BiteCod WormScarred Para-BiteRound WormNightcrawlerRoundyUlcer
Leeches LeechKamikaze LeechHoly Leech
Poop DipCorn DipBrown DipSquirtDank SquirtDinga
Skeletons BonyBlack BonyDeath's HeadDank Death's HeadFlesh Death's Head
Ghosts Lil' HauntWizoobRed Ghost
Bats One ToothFat Bat
Fatties FattyFlaming FattyConjoined FattyBlue Conjoined FattyPale Fatty
Hosts HostRed HostWalking HostWalking Red Host
Vises VisDouble VisChubberCage VisScarred Double Vis
Tumors TumorPsy TumorCamillo Jr.
Spikes Wall HuggerSlidePoky
Babies BabyAngelic BabyEmbryoImp
Homunculuses HomunculusBegotten
Keepers KeeperHanger
Grimaces Stone GrimaceVomit GrimaceGaping MawTurret GrimaceBrimstone Grimace
Oobs OobBlack Maw
Others FredLumpB. LickerDukieDopleEvil TwinMeatball

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