Harlequin Baby is an item familiar added to the Wrath of the Lamb DLC for the original game, and in the Rebirth remake. As its name suggests, it appear as a baby with swollen lips, red eyes, and no skin.
Spawns familiar that shoots a pair of blood tears diagonally every second while Isaac is firing.
- This item is based on a real medical condition named Harlequin Ichthyosis that deforms infants, causing them to have scaly skin, a strangely shaped body, and sunken, red eyes and lips.
- This familiar looks very similar to Mr. Fred, a boss added to Rebirth.