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- Not to be confused with the enemy Guts.
They can replace regular Boils, and appear naturally in Necropolis.
Instead of firing multiple short-ranged blood shots, Guts fire explosive shots (similar to the IPECAC item) at Isaac that do not damage themselves.
They can easily be a nuisance if there are other enemies backing them. However, they are rather easy to manipulate into destroying rocks or finding Secret Rooms without using a bomb.