- Not to be confused with the enemy Guts.
Guts are green-colored variants of regular Boils added in the Wrath of the Lamb expansion for the original game, and also appear in the Rebirth remake.
They can replace regular Boils, and appear naturally in Necropolis.
Instead of firing multiple short-ranged blood shots, Guts fire explosive shots (similar to the IPECAC item) at Isaac that do not damage themselves.
They can easily be a nuisance if there are other enemies backing them. However, they are rather easy to manipulate into destroying rocks or finding Secret Rooms without using a bomb.
Eternal Champion Behavior
Eternal Guts fire three explosive shots instead of one. They are some of the easiest Eternal enemies to defeat, as they still do not attack if they are not at full size.