The look identical to awoken Frowning Gapers, but have green-tinted skin and they are more hunched back.
They shoot IPECAC shots at Isaac at very short range. These shots will kill other enemies in their area of effect, but Gurgles themselves are immune to their own shots. Like other enemies' explosive projectiles, Gurgles' shots can be used to shatter Rocks or open Secret Rooms by making Gurgles fire at the appropriate area.
Gurgles are somewhat more predictable and accurate in their shots compared to guts and walking guts, because they will always shoot at Isaac's position. However, the timing of their shots is unpredictable. As such, an effective strategy of delivering explosives to a particular area (e.g. Tinted Rock or potential secret room entrance) is to stand still in that position as long as possible before moving to avoid getting touched, in order to prompt the Gurgles to shoot their projectiles at Isaac.
- In Rebirth, Gurgles may spawn Splashers upon death.
- If a slowing item is used, such as the The Hourglass, Gurgles will shoot two red IPECAC shots at the player instead of one.
- When Gurgles are slowed by an item, such as Spider's Bite or The Hourglass, their walking animation will not play.