Globins attempt to directly charge at the player, similar to Gapers; however, they are much faster. Instead of dying, they will crumble into goo after taking a certain amount of damage and then regenerate anew unless destroyed in their puddle-of-goo form. After killing a Globin for the first time, they become much easier to down. Because of their speed, Globins have the tendency to overshoot the player's position in rooms with a large number of obstacles, which can lead to the player being quickly surrounded on all sides if care is not taken. A tip on avoiding being surrounded is to remember that your tears do have moderate knockback that can open a window in a seemingly airtight formation.
Each time a Globin collapses it counts as a kill; this can be exploited to either refill the recharge bar for items, or with the Charm Of The Vampire to (slowly) refill health and increase damage with Rage passive item, although patience is required for these.
An alternate version exists which has an eye in one of its sockets and a much more contorted face. This one runs faster, takes more hits to destroy, and slides away from the player while collapsed.
- If you manage to isolate yourself on a different chunk of land like shown in the picture, they will stop chasing you until you go back onto the same chunk of land they are. Note that if you are simply on a ladder next to a wall they will still chase you. (Confirmed Version 1.48 Wrath of the Lamb)