Gish's attack pattern is similar to that of Monstro II. However, instead of a blood beam, he attacks with exploding projectiles that leave behind puddles of tar that slow down Isaac. Instead of Monstro II's Sucker-spawning attack, Gish spawns two smaller Clots based on himself. Unlike with Monstro II, his first stomping attack does not produce any projectiles.
Gish is an easy boss once you get the hang of his attack patterns. His leaps into the air are easy to avoid and his spawned Clotties are simple enemies. His tar ball attack is easy to dodge, as the player can just run in a circle and Gish will usually miss. With this fight, patience is the key.
- Gish is a character from Edmund's game, Gish. Gish was also an unlockable in another of Edmund's games, Super Meat Boy and the free flash game Meat Boy, and appeared as a part of customization in his game Host.
"I Have Sticker Fingers..." - Defeat Gish.
|Basement||Larry Jr. • Monstro • The Duke of Flies • Gemini • Steven • Famine|
|Cellar||Widow • Pin • The Duke of Flies • Famine • Gurdy Jr. • The Blighted Ovum|
|The Caves||Fistula • Peep • Gurdy • Chub • C.H.A.D. • Pestilence|
|Catacombs||The Husk • The Hollow • The Blighted Ovum • The Carrion Queen • Peep • Pestilence • The Wretched • Gurdy Jr.|
|The Depths||Loki • Monstro II • Gish • War • Mom|
|Necropolis||Mask of Infamy • Daddy Long Legs • The Carrion Queen • The Bloat • Loki • War • The Wretched • Mom|
|The Womb||Scolex • Blastocyst • The Bloat • Death • Conquest • Daddy Long Legs • Triachnid • Teratoma • Mom's Heart • It Lives|
|Utero||Teratoma • The Bloat • Death • Conquest • Daddy Long Legs • Triachnid • Lokii • Mom's Heart • It Lives|
|Sheol||The Fallen • Satan|
|First to fifth and seventh level||The Fallen • Headless Horseman|