For other uses, see Fly (disambiguation).
For the monster from The Legend of Bum-bo, see Fly.

Black Flies (ブラックフライ Burakkufurai), also known as Flies for short, are one of the most common enemies, found in almost all chapters. They can naturally spawn in The Basement. They also come in sort of multiple variants.


Black Flies buzz around the room randomly, making buzzing noises, often moving away from the player. They cannot damage Isaac at all, even by touch, making them completely harmless. However, they can turn into relatively dangerous Pooters if they fly around the Poop for too long or come in contact with a golden poop.



  • They appear in the original game.
  • Black Flies, along with other type of flies, are one of the enemies with lack of champion variants.
    • Same apply to Spiders and few other monsters.
  • From the original game, few Black Flies can be seen from the menu screen before starting the game.
    • In Rebirth, however, never appear in the menu screen but few sprites still can be found in the game files.
Black FlyAttack FlyMoterEternal FlyPooterFat FlyBoom FlyRed Boom FlyDrowned Boom FlySuckerSpitDart FlySwarm FlyRing FlyLevel 2 FlyFull FlyHush FlyBall of FliesSpiderBig SpiderTriteRaglingRag TriteLevel 2 SpiderTicking SpiderBaby Long LegsCrazy Long LegsWall CreepBlind CreepRage CreepPara-BiteCod WormScarred Para-BiteRound WormNightcrawlerRoundyUlcerMaggotChargerSpittyConjoined SpittyDrowned ChargerGrubClottyClotMega ClottyLeechKamikaze LeechHoly Leech
BoilGutSackBlue BoilHostRed HostWall HuggerSlidePokyStone GrimaceVomit GrimaceGaping MawTurret GrimaceBrimstone Grimace
MulliganMulligoonMulliboomHiveSwarmerNestDrowned HiveHopperFlaming HopperLeaperPacerGusherSplasherGaperFrowning GaperGurgleMr. MawFlaming GaperCyclopiaSkinnyRottyNullGreed GaperBlue GaperSwingerHorfPsychic HorfGlobinGazing GlobinBlack GlobinDank GlobinKnightSelfless KnightFloating KnightBone KnightBonyBlack BonyFattyFlaming FattyConjoined FattyBlue Conjoined FattyPale FattyKeeperHangerVisDouble VisChubberCage VisScarred Double VisHomunculusBegottenDopleEvil Twin
Body parts
Mask + HeartBrainMemBrainGutsMama GutsEyeBloodshot EyeMom's HandDead Mom's HandScarred GutsNerve EndingStone Eye
DipCorn DipBrown DipSquirtDank SquirtDinga
MawRed MawPsychic MawDeath's HeadDank Death's HeadFlesh Death's HeadLil' HauntWizoobRed GhostOne ToothFat BatTumorPsy TumorCamillo Jr.BabyAngelic BabyImpDukieOobBlack Maw
FredLumpEmbryoB. Licker

Start a Discussion Discussions about Black Fly

  • More than 3 orbitals?

    3 messages
    • It will have no effect whatsoever, unless the orbital you find is better than one of those you already have, in which case it will replace it.
    • you can gey up to 5 orbitals using the monster manual
  • Black fly gained quite a bit of weight fast...

    8 messages
    • It happened because if a normal, black fly hover around poop for a while, it might turn into a pooter, those flies that shoot blood shots. ...
    • I had a Fat fly(the two shot one) change into a pooter and I had no clue what happend.

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