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Black Fly

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In-game sprite


Effective item(s):

Black Flies are very common enemies, found in almost all floors. They can naturally spawn in The Basement, and can be spawned by the Duke of Flies, The Husk, Hives, Swarmers, Gurdy, and Pestilence. They also come in sort of multiple variants.


Black flies buzz around the room randomly, often moving away from the player. They cannot damage Isaac at all, even by touch, making them completely harmless. However, they can turn into relatively dangerous Pooters if they fly around Poop for too long.



  • If the host of an Eternal Fly is destroyed while it is frozen due to the use of items such as Mom's Bra, the fly will simply sit in the same spot without doing anything, being pushed by any tears shot at it.


More info coming soon.

More info coming soon.

More info coming soon.

Flies Black FlyAttack FlyMoterEternal FlyPooterFat FlyBoom FlyRed Boom FlyDrowned Boom FlySuckerSpitDart FlySwarm FlyRing FlyLevel 2 FlyFull Fly
Spiders SpiderBig SpiderTriteRaglingLevel 2 SpiderTicking SpiderBaby Long LegsCrazy Long LegsWall CreepBlind CreepRage Creep
Spheres BoilGutSackBlue BoilWalking BoilWalking GutWalking Sack
Mulligans MulliganMulligoonMulliboomHiveSwarmerNestDrowned Hive
Headless HopperFlaming HopperLeaperPacerGusherSplasher
Gapers GaperFrowning GaperGurgleMr. MawFlaming GaperCyclopiaSkinnyRottyNullGreed GaperBlue GaperSwinger
Heads HorfPsychic HorfMawRed MawPsychic Maw
Globins GlobinGazing GlobinBlack GlobinDank Globin
Knights KnightSelfless KnightFloating KnightBone Knight
Blobs ClottyClotI. BlobMega Clotty
Maggots MaggotChargerSpittyConjoined SpittyDrowned Charger
Body parts Mask + HeartBrainMemBrainGutsMama GutsEyeBloodshot EyeMama's HandDead Mama's HandScarred GutsNerve EndingStone Eye
Worms Para-BiteCod WormScarred Para-BiteRound WormNightcrawlerRoundyUlcer
Leeches LeechKamikaze LeechHoly Leech
Poop DipCorn DipSquirtDank SquirtDinga
Skeletons BonyBlack BonyDeath's HeadDank Death's HeadFlesh Death's Head
Ghosts Lil' Haunt'WizoobRed Ghost
Bats One ToothFat Bat
Fatties FattyFlamming FattyConjoined FattyBlue Conjoined FattyPale Fatty
Hosts HostRed HostWalking HostWalking Red Host
Vises VisDouble VisChubberScarred Double Vis
Tumors TumorPsy TumorCamillo Jr.
Spikes Wall HuggerSlidePoky
Babies BabyAngelic BabyImp
Homunculuses HomunculusBegotten
Keepers KeeperHanger
Grimaces Stone GrimaceVomit GrimaceGaping MawTurret GrimaceBrimstone Grimace
Oobs OobBlack Maw
Others FredLumpB. LickerDukieDopleEvil TwinMeatball

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