Up to three eyes will appear in a room, often near the center. They occasionally spawn in the corners, making them difficult to kill without taking damage.
Extremely dangerous when paired with Vis, since circle strafing will usually get you hit. Instead, try to change directions at the right moment when the eye charges, if a Vis is about to shoot its laser in your path. Bombs are also helpful, as both Vis and Eye stop to fire.
In Sheol, and on rare occasions in the womb, a variation appears which shoots a broad blood stream (Similar to Brimstone and Gluttony/Vis) instead of a laser. The bloodstream can also pass through walls. This variation can also appear in the womb as a champion form of normal eyes (even in the boss battle for the Womb 2).
Bug: In some cases the beam of the Sheol variants does not reach from corner to corner. This may be a graphical glitch. While the beam graphic does not reach the opposite corner, it will still deal damage as if it had, making hiding out of range of the beam futile.
- Eye is a reference to the Beamos, originating from The Legend of Zelda: A Link to the Past. Both normally are placed in the middle of a room from where they follow the player's movement to shoot them if they stand still for too long.
- Eyes are also similar to an enemy from Super Meat Boy that behaves the same way, following the player and shooting lasers.