Monster
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Description
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Eternal Variant (Hard Mode only)
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WotL
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Black Fly
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Tiny black flies that do not hurt Isaac upon touch.
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Attack Fly
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Red Flies that follow Isaac and deal touch damage.
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Moter
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Follows Isaac, similar to Attack Flies. Will split into 2 Attack Flies upon death.
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Splits into 4 Attack Flies instead of 2.
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Eternal Fly
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Invulnerable Fly that circles Corny Poop, Holy Leeches or Hangers.
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✔
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Pooter
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Slow-moving flies that fire single blood shots at Isaac. Pooters do not deal contact damage.
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Fires 3 shots in quick succession.
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Fat Fly
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Alternate version of Pooters. Fires 2 shots in a V-formation and does not deal contact damage.
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Fires 3 sets of 3 shots in a V-formation.
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✔
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Boom Fly
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Flies around the room diagonally, dealing touch damage and exploding with a large blast radius upon death.
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Explodes with very large blast radius upon death.
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Red Boom Fly
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Flies around the room diagonally, dealing touch damage and exploding into 6 directional blood shots upon death.
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Explodes into a dense ring of blood shots upon death.
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Sucker
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Flies slowly towards Isaac, exploding into 4 projectiles in a + formation upon death.
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Shoots 4 projectiles in a + formation, exploding into 8 blood shots upon death.
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Spit
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Flies slowly towards Isaac, exploding into an IPECAC shot upon death which targets other Spits in the room, or Isaac.
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Shoots 4 projectiles diagonally, exploding into 3 IPECAC shots upon death.
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✔
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Spider
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Moves erratically around the room, damaging Isaac by touch.
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✔
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Big Spider
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Moves erratically around the room, splitting into two Spiders upon death.
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Explodes into many Spiders upon death.
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✔
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Trite
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Quickly jumps towards Isaac with high distance. If Isaac is too far away it will jump around randomly.
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Leaves slowing creep and shoots 4 projectiles in a + formation wherever it lands.
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✔
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Boil
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Stationary enemy that shrinks upon being hit. Will quickly swell up if not killed in time. Fires multiple short-ranged blood projectiles when fully swollen.
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Fires a larger volley of blood projectiles.
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Gut
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Stationary enemy that shrinks upon being hit. Will quickly swell up if not killed in time. Fires an IPECAC shot when fully swollen.
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Fires 3 IPECAC shots instead of one.
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✔
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Sack
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Stationary enemy that shrinks upon being hit. Swells up slower than Guts and Boils. Spawns a Spider when fully swollen.
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Spawns two Spiders instead of one.
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✔
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Walking Boil
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Mobile Boil that cannot shrink, but has a finite amount of health. Fires short-ranged blood shots with varying sizes at a reduced fire rate.
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Fires a larger volley of blood projectiles.
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✔
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Walking Gut
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Mobile Gut that cannot shrink, but has a finite amount of health. Fires IPECAC shots at a reduced fire rate.
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Fires 3 IPECAC shots instead of one.
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✔
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Walking Sack
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Mobile Sack that cannot shrink, but has a finite amount of health. Spawns Spiders.
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Spawns two Spiders instead of one.
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✔
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Mulligan
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Harmless enemy that walks around the room, avoiding Isaac. Will spawn multiple flies upon death.
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Periodically fires 4 shots in a + formation whenever Isaac is standing to that formation.
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Mulligoon
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Harmless enemy that walks around the room, avoiding Isaac. Will drop a Troll Bomb upon death.
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Periodically spawns Spiders while running away.
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Mulliboom
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Walks towards Isaac, exploding with a large blast radius upon death or upon touching Isaac. The explosion does a half-heart of damage instead of the regular full heart.
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Continuously fires two IPECAC shots while walking.
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✔
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Hive
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Walks around the room, avoiding Isaac while spawning Attack Flies. Spawns a large number of Flies upon death.
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Spawns two flies instead of one each time, and spawns more flies upon death. Can sometimes be a mini-boss with health bar and larger body, spitting eternal flies and has orbital eternal flies.
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Swarmer
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Slowly floats around the room, spawning a Pooter upon taking damage. Spawns a large number of Flies upon death.
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Spawns Eternal Flies instead of regular Flies, one Pooter and one Eternal Fly when damaged, and will split into 3 non-Eternal Swarmers when killed.
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✔
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Hopper
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Jumps around the room slowly, damaging Isaac by touch.
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Stands still before start pursuing Isaac, firing 4 blood projectiles in a + formation after it lands.
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Flaming Hopper
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Jumps around the room quickly, covering a large distance, similar to Trites.
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Stands still before start pursuing Isaac, firing 4 blood projectiles in a + formation after it lands.
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Leaper
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Jumps around the room quickly, but not as fast as F. Hoppers. Occasionally jumps high into the air, dropping down elsewhere while firing 4 blood shots in a plus pattern.
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Stands still before start pursuing Isaac, firing 4 blood projectiles in a + formation after it lands, and 8 blood shots in all directions after the big jump.
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Pacer
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Walks aimlessly around the room. Usually spawned after killing a Gaper/Frowning Gaper.
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Gusher
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Walks aimlessly around the room, firing extremely short-ranged blood projectiles from its head. Usually spawned after killing a Gaper/Frowning Gaper.
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Walks towards Isaac, firing fast projectiles in Isaac's general direction.
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Gaper
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Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or Gusher upon death.
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Always turns into an Eternal Gusher or Eternal Horf upon death.
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Frowning Gaper
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Walks towards Isaac, dealing contact damage. If Isaac is in sight, its eyes will open and it will walk faster. Usually turns into a Pacer or Gusher upon death.
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Always turns into an Eternal Gusher or Eternal Horf upon death.
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Gurgle
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Slowly walks towards Isaac, firing short-ranged IPECAC shots at him. Has much more health than regular Gapers.
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Leaves a trail of damaging creep and fires a long-ranged homing IPECAC shot at Isaac.
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✔
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Mr. Maw
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Walks towards Isaac, quickly launching its head, still attached to its body by a cord. Turns into a Maw or Pacer upon death.
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Shoots 8 shots in all directions every time it shoots its head.
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Horf
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Stationary enemy that fires medium ranged blood shots at Isaac.
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Shoots a wide spread of 5 blood shots each time.
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Maw
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Floats towards Isaac, firing fast-moving blood shots.
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Fires spread volleys of 9 blood projectiles.
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Red Maw
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Floats towards Isaac faster than regular Maws, exploding into 4 blood shots in a plus pattern upon death. Does not fire any shots.
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Constantly leaves red creep and explodes into 8 shots in all directions upon death.
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Psychic Maw
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Alternate version of a Maw, has an Eternal Fly circling it. Fires large, purple homing shots at Isaac.
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3 Eternal Flies instead of one.
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✔
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Globin
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Walks towards Isaac, dealing one heart of contact damage. Turns into a pile of goo after taking enough damage, where it can be killed. Will regenerate after a short amount of time if not killed quickly.
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Fires a ring of 8 blood projectiles after collapsing into a pile of goo.
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Gazing Globin
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Quickly walks towards Isaac, dealing one heart of contact damage. Turns into a pile of goo and slides away after taking enough damage, where it can be killed. Will regenerate after a short amount of time if not killed quickly.
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Fires a ring of 8 blood projectiles after collapsing into a pile of goo, also keeping firing while slide away.
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Knight
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Moves erratically around the room. Can only be damaged from behind.
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Reflects Isaac's shots on its face and leaves red creep each time it takes damage.
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Selfless Knight
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Moves erratically around the room, charging at Isaac at very high speed. Can only be damaged from behind.
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Reflects Isaac's shots on its face and leaves red creep each time it takes damage.
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Mask + Heart
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Invulnerable mask with a slow-moving Heart. Functions similarly to a Knight. The Heart fires 4 blood shots in a plus pattern when Isaac gets near. Killing the Heart will automatically kill the Mask.
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Eternal Heart fires 8 shots in all directions in quick succession, shooting 4 shots in the cardinal directions upon death. Eternal Mask immediately teleport back to the corresponding Heart and start charging should the Heart take damage.
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✔
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Clotty
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Moves around the room, firing 4 blood shots in a + pattern.
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Fires 3 sets of 4 blood projectiles in a + pattern as well as multiple various-sized blood projectiles in random directions.
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Clot
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Moves around the room, firing 4 tar shots in an X pattern.
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Fires 3 sets of 4 blood projectiles in an X pattern as well as multiple various-sized blood projectiles in random directions.
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I. Blob
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Moves around the room, firing 8 shots in all directions.
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Fires 3 sets of 8 blood projectiles in all directions as well as multiple various-sized blood projectiles in random directions while also slowly move toward Isaac.
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✔
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Maggot
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Aimlessly moves around the room, damaging Isaac by contact.
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Leaves green creep, and after a few seconds, it will transform into an Eternal Sack, which will in turn after a few seconds transform into an Eternal Fat Fly.
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Charger
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Slowly moves around the room, charging at Isaac when he gets in its line of sight.
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Leaves green creep, and after a few seconds, it will transform into an Eternal Sack, which will in turn after a few seconds transform into an Eternal Fat Fly.
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Spitty
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Slowly moves around the room, firing a single long-ranged blood shot when Isaac gets in its line of sight.
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Fires 3 projectiles, one in the center and two in a V-formation when Isaac gets in its line of sight.
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Brain
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Crawls around the room, leaving a trail of red Creep that does one heart of damage.
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Shoots a homing blood shot at Isaac.
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MemBrain
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Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Will split into 2 Brains upon death.
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Shoots 8 homing blood shots and spawns 3-4 Eternal Brains upon death.
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Guts
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Attaches itself to a wall or obstacle, such as a Rock, rolling around the room.
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Moves faster and occasionally shoots 8 shots in all directions.
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Mama Guts
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Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions. Will split into 2 Guts upon death.
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Fires 8 large blood shots in quick succession and spawns 2 Eternal Guts and 1 Eternal Clotty upon death.
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✔
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B. Licker
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Attaches itself to other B. Lickers, erratically moving around the room, similar to Larry Jr.
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Starts pursuing Isaac, leaving behind red creep.
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✔
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Para-Bite
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Moves towards Isaac. Can burrow underground and reappear elsewhere.
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Stops pursuing Isaac, spawning 3 smaller Eternal Para-Bites that is close to him.
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Fred
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Fires an IPECAC shot at Isaac. Will hop out of the ground and burrow elsewhere, firing 4 blood shots in an X pattern while doing so.
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Fires a homing IPECAC shot at Isaac, leaving 8 shots in all directions when diving into ground.
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Lump
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Fires 3 fast-moving blood shots at Isaac when he gets in its line of sight. Will burrow underground and reappear elsewhere after firing its shots.
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Fires 3 blood shots in quick succession.
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Leech
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Quickly charges towards Isaac when he gets in its line of sight.
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Kamikaze Leech
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Quickly charges towards Isaac when he gets in its line of sight. Explodes with a large blast radius upon death.
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Shoots continuous shots to both sides while moving and has an Eternal Fly circling it.
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Holy Leech
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Quickly charges towards Isaac when he gets in its line of sight. Explodes with a large blast radius upon death. Has an Eternal Fly circling it.
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Shoots continuous shots to both sides while moving.
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✔
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Host
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Invulnerable stationary enemy. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will fire 3 blood shots and lower its head again.
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Invulnerable stationary enemy that reflects Isaac's tears. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Upon raising its head, it will either fire 5 blood shots in a V formation and lower its head again, or quickly lower its head and fire 8 shots around it.
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Red Host
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Stationary enemy that can be damaged even when its head is lowered. Fires 5 blood shots instead of 3 when rising, and fires more frequently.
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Fires 7 blood shots in quick succession. Sometimes, it quickly lower its head and fire 8 shots around it.
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Vis
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Charges up a Brimstone laser when Isaac gets in its line of sight.
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Double Vis
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Charges up a Brimstone laser which fires from both sides when Isaac gets in its line of sight.
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Leaves red creep each time it fires a Brimstone laser.
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✔
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Chubber
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Fires a Little Chubby-like familiar that deals one heart of damage when Isaac gets in its line of sight.
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Leaves red creep each time it shoots a Charger.
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✔
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Poky
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Moves around the room, damaging Isaac by contact.
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Slide
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Quickly slides towards Isaac when he gets in front of it.
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✔
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Eye
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Quickly fires a Technology-like laser at Isaac.
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Occasionally shoot continuous blood shots. When this happens, it will keep spinning until it stops after a few seconds.
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Bloodshot Eye
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Quickly fires a Brimstone-like laser at Isaac.
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Dople
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Copies Isaac's movements, and fires tears at the same time as him.
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Evil Twin
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Copies Isaac's movements, and fires tears at the same time as him.
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Embryo
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Aimlessly hops around the room, damaging Isaac by contact damage.
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Shoots large rings of blood shots every time it jumps. Upon taking enough damage, it splits into 4 smaller Eternal Embryos that shoot less blood shots. Smaller Eternal Embryos, however, can only split into 2 even smaller ones, and they no longer shoot blood shots if they are smaller than half-sized ones.
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Baby
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Fires a single blood shot at Isaac. Can teleport and reappear elsewhere.
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Leaves 4 blood shots in a + pattern when teleporting.
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Angelic Baby
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Fires 3 blood shots at once at Isaac, has much more health than regular Babies.
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Leaves 8 blood shots in all directions when teleporting.
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✔
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Keeper
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Hops around the room, firing 2 blood shots in a V formation at Isaac.
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Stands still before start pursuing Isaac, firing 4 shots each time it lands and also fires 2 shots in quick succession at Isaac.
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✔
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Hanger
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Floats around the room, firing 3 blood shots at Isaac. Has an Eternal Fly circling it.
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Fires 3 homing blood shots at Isaac.
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✔
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Stone Grimace
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Stationary and invulnerable monster that fires a fast-moving blood shot at Isaac. Stops firing when room is cleared.
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Vomit Grimace
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Stationary and invulnerable monster that fires an IPECAC shot at Isaac. Stops firing when room is cleared.
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✔
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