E. Coli is a passive item introduced in The Binding of Isaac Rebirth. It looks like a scaled up representation of a bacterial cell.


Isaac's head becomes covered in feces after gaining this item.

Also, any non-boss enemy touched will turn into poop, similar to how the Flush turns all enemies in the room into poop.


This works with the Midas Touch to turn enemies into golden poop, making the combination very profitable.


Escherichia coli is an actual bacterium found in the lower intestine of warm-blooded organisms. Most strains of this bacterium are harmless, but there are pathogenic ones that this item refers to. Unlike the actual rod-shaped E. Coli, the item's body is rounder, and possesses a flagellum (tail).


  • If you use Punching Bag, the mulligan you have summoned may turn into poop.

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