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Beside their noticeable single eye, their mouth appears to be drooling with some blood, unlike other Gaper-type variants.
They move slower than regular Gapers, and can leave behind a trail of harmful red creep. They occasionally fires a bullet out from their mouths at Isaac.
- Sometimes, a pair of Cyclopias will appear during the boss battle against Monstro.
- After getting shrunk by Isaac's tears with God's Flesh effect, the Cyclopia still shoot bullet-shots at Isaac, unlike other enemies that runs away from Isaac after they shrink.
- Their appearance and name is based on cyclopia, a gruesome yet extremely rare birth defect that causes the infant to be born with a single eye, similar to the Greek mythological monster Cyclops.
- Cyclopia is one of the Gaper types not to spawn into headless variants upon death. Three others being Blue Gaper, Null, and Greed Gaper.