Creep is a fluid produced by various Monsters, Bosses, and Collectables. It affects either Isaac or Monsters and Bosses in certain ways when they come in contact with it, unless they are Flying. All Creep will dissipate after a set amount of time.
Types of Creep
Red Creep is the most common type of Creep, differentiated from regular blood by its glowing nature. It can be left by explosive red projectiles, or a trail behind certain Monsters as they move. Red Creep deals a full heart of damage to Isaac upon touch and is harmless to Monsters and Bosses.
|The Blighted Ovum||Brain|
|Mom's Heart/It Lives!|
Green Creep is functionally identical to Red Creep, damaging Isaac for a full heart when touched and not affecting Monsters or Bosses.
Yellow Creep damages Isaac for a half-heart when touched. It is spawned only by the boss Peep.
A beneficial type of yellow Creep can be spawned by using Lemon Mishap, which damages enemies instead of Isaac. Peep is just DISGUSTING!
Black Creep deals no damage to Isaac, but slows him down, similar to Cobwebs. Monsters and Bosses however, are unaffected by it.
|Black champion Widow|
Added in the Wrath of the Lamb DLC, White Creep deals no damage to Isaac, but slows him down, similar to Cobwebs. Monsters and Bosses however, are unaffected by it.
|White champion Pestilence|
Blue Creep is a beneficial type of Creep left by the Holy Water item, which activates upon Isaac taking damage. It damages Monsters that come in contact with it and is harmless to Isaac.