In-game sprite from the original game.
The Depths (uncommon)
Clotty is a monster in The Binding of Isaac and the Rebirth remake which appears to be a living blob of blood with a bone in its head, making its appearance to resemble a meat. It can be randomly found on any floor, ranging from The Basement to The Cathedral.
Clotty slowly crawls in random directions, shooting blood projectiles in the cardinal directions every three seconds, making it hard to hit without taking damage. If there are multiple Clotties in a room, the use of bombs or activated items like The Necronomicon is highly recommended. Having spectral or homing tears will make engagements with them much easier as well.
- Their appearance may based on Super Meat Boy, the main protagonist from the game of the same name also developed by Edmund McMillen.