Clots flit about the room haphazardly, firing black projectiles in diagonal directions at random intervals. It is much easier to defeat than Clotty, since you will be perfectly safe if you shoot at it while standing directly in front or to the side of it. It is only truly dangerous when there are other enemies in the room.
- The Clot resembles a black blob with yellow eyes and white teeth, and is almost identical to the protagonist Gish, from the game of the same name, which was also created by Edmund McMillen.
- In the credits, the picture of the Clot looks like the top half of a Clotty, indicating a possible change in the design of the Clot during the game's development.
- When a Clot is in the room, using bombs or defeating other enemies will leave the same black goo marks as Clots. Ranged enemies will also shoot the same black projectiles as the Clots.