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Xxx form2Isaac Rebirth

This article refers to the trinket. For the passive item, see Cancer.

Cancer is a trinket first added to the Wrath of the Lamb DLC for the original game, and also appear in the Rebirth remake.


  • Decreases tears delay by 2.


  • The effective fire rate increase varies depending on Isaac's current Tears stat. The higher the Tears stat, the higher the percentage increase in fire rate from Cancer.
Starting Trinkets
AAA BatteryAce of SpadesBlasting CapBible TractBlisterBob's BladderBroken MagnetBroken RemoteBrown CapButt PennyCallusCancerCartridgeChild's HeartChild's LeashCursed SkullEndless NamelessErrorFaded PolaroidFish HeadFlat PennyFlat WormGoat HoofGolden Horse ShoeHook WormIsaac's ForkLazy WormLiberty CapLil LarvaLouseMatch StickA Missing PageMom's LocketMom's PearlMom's ToenailMonkey PawMysterious CandyNO!Paper ClipPetrified PoopPinky EyePurple HeartPush PinPulse WormRainbow WormRed PatchRing WormRosary BeadRusted KeySafety CapSafety ScissorsSecond HandShiny RockSuper MagnetTape WormThe TickUmbilical CordWatch BatteryWiggle WormWhip Worm
Unlockable Trinkets
???'s SoulBlack FeatherBlind RageBloody PennyBroken AnkhBurnt PennyCain's EyeCounterfeit PennyCracked DiceCurved HornDaemon's TailEve's Bird FootIsaac's HeadJudas' TongueKarmaThe Left HandLucky ToeLucky RockMaggy's FaithMissing PosterMysterious PaperPoker ChipRib of GreedSamson's LockStore KeyStore CreditStud FinderSwallowed Penny
TBoI-only Trinkets
The PolaroidGame Squid

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