- This item refers to the trinket. For the character, see Cain.
Cain's Eye is a trinket first added to the Wrath of the Lamb DLC, and also appear in the Rebirth remake. It appear as just an eyeball.
It is unlocked after defeating ??? as Cain.
- When starting a floor, 25% chance to get the The Compass effect for the duration of a floor.
- This trinket is a reference to Cain as he lost one of his eyes.
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