Brains are enemies appearing in The Binding of Isaac and the Rebirth remake. They can commonly be found in The Depths and The Womb.
Brains move around the room slowly, leaving a trail of red Creep
that does one full heart of damage to Isaac. They are relatively weak on their own, but can quickly corner Isaac when fought in groups.
- 2 Brains can be spawned after killing MemBrain.
- In the original game, Brains flash in color red for few seconds every time while moving. However, they no longer does so in Rebirth.