At the end of each floor, the player must fight a boss. The boss will be randomly chosen based on which area the player is currently in. Some bosses can be specially coloured like normal enemies, which can change their pattern somewhat; this occurs more often once the player has beat the full game for the sixth time and onwards.

Upon death, bosses either drop an item which increases a single stat or an item unique to that particular boss. In addition, they drop random health pickups; two at the start or one after unlocking "Everything is Terrible". If the boss was an alternative version, it drops one additional random health pickup upon death.

Contents 1 Bosses 1.1 The Basement 1.2 The Cellar 1.3 The Caves 1.4 The Catacombs 1.5 The Depths 1.6 Necropolis 1.7 The Womb 1.8 Utero 1.9 Sheol 1.10 Cathedral 1.11 The Chest 1.12 Anywhere 1.13 Devil Room 2 Unlockable Bosses 2.1 Harbingers 2.2 Alternative Bosses 3 Mini-Bosses 3.1 The Seven Deadly Sins 3.2 The Seven Super Deadly Sins 3.3 Ultra Pride 4 Boss Treasures 5 Trivia

BossesEdit

The BasementEdit

The CellarEdit

(Wrath of the Lamb expansion)

The CavesEdit

The CatacombsEdit

(Wrath of the Lamb expansion)

The DepthsEdit

NecropolisEdit

(Wrath of the Lamb expansion)

The WombEdit

(Unlocked after defeating Mom)

UteroEdit

(Wrath of the Lamb expansion)

Sheol Edit

Added in the Halloween update, 100% chance to enter after ending 10. Defeating Mom's Heart without taking a hit prior to the 10th ending increases your chances to enter.

Cathedral Edit

Added in Wrath of the Lamb, 100% chance to enter after ending 10.

The ChestEdit

(Wrath of the Lamb expansion v1.3)

After defeating Isaac while holding The Polaroid trinket, opening the golden chest in the middle will take you to The Chest instead of displaying ending 12.

AnywhereEdit

(Except for floors where "final bosses" appear.)

Devil RoomEdit

Unlockable BossesEdit

Harbingers Edit

These bosses are only available after defeating Mom for the first time, where after the credits you will unlock the secret "The Horsemen are on the loose!". They drop a meat cube upon defeat, and the player can fight all of them in one playthrough by using the Book Of Revelations.

• Famine (The Basement)
• Pestilence (The Caves)
• War (The Depths)
• Death (The Womb)
• Headless Horseman (May appear as a boss in almost any floor.)
• Conquest (Added in the Wrath of the Lamb expansion.)

Alternative BossesEdit

These bosses are only available after finding their respective unlocks.

• Steven (Alt for Gemini, unlocked by completing The Basement 25 times)
• C.H.A.D. (Alt for Chub, unlocked by completing The Caves 20 times)
• Gish (Alt for Monstro II, unlocked by completing The Depths 15 times)
• Triachnid (Alt for Daddy Long Legs unlocked by completing The Womb 15 times)
• It Lives (Replaces Mom's Heart, unlocked after beating Mom's Heart nine times)

Mini-BossesEdit

Each level has a chance to include a Special Room where the player can face a mini-boss

The Seven Deadly SinsEdit

• Envy
• Gluttony
• Greed
• Lust
• Pride
• Sloth
• Wrath

The Seven Super Deadly SinsEdit

The "Super Deadly Sins" were added in the Wrath of the Lamb expansion and will sometimes appear instead of the regular version of the accordant Deadly Sin.

• Super Envy
• Super Gluttony
• Super Greed
• Super Lust
• Super Pride
• Super Sloth
• Super Wrath

Ultra PrideEdit

The boss called Ultra Pride was added into the Wrath of the Lamb expansion in version 1.3. Upon defeating him, the achievement and item The Left Hand is unlocked.

Boss TreasuresEdit

Boss Drops
Common Drops
Breakfast Lunch Dinner Dessert Rotten Meat Pentagram Super Bandage Mom's Underwear Mom's Heels Mom's Lipstick Wire Coat Hanger Wooden Spoon The Belt
Wrath of the Lamb additions
Box Pageant Boy Cat-O-Nine-Tails Squeezy Stem Cells Jesus Juice Magic 8 Ball Mom's Coin Purse MEAT!
Boss Specific Drops
Little C.H.A.D. (Dropped by C.H.A.D.) Little Gish (Dropped by Gish) Daddy Longlegs (Dropped by Daddy Long Legs and Triachnid) Steven or Little Steve (Dropped by Steven) Cube Of Meat (Dropped by any of the Horseman of Apocalypse or the Headless Horseman) A Pony (Dropped by the Headless Horseman) White Pony (Dropped by Conquest) A Lump Of Coal (Dropped by Krampus) Any Devil Room Item (Dropped by the Fallen when not facing Satan)

TriviaEdit

• If you have extra lives, either from collecting a 1UP, Ankh, or Guppy, bosses can be re-fought at the cost of one life in order to collect more items. After defeating a boss, don't immediately pick up the item on the pedestal. Instead, kill yourself with bombs or spikes, fires, etc. You will respawn outside the boss room, and the boss will return to life. You can fight the boss a second time to produce a second item. This can be done as many times as you have extra lives.

• Most of the bosses, in particular ones like Gemini, are heavily suggested to be the lost siblings of Isaac. How most of Isaac's "siblings" survived in the murky depths of the basement is unknown, although it is clear that many of them have adapted, and in cases like Peep, have developed grotesque abilities to use to defend themselves. Considering that many of them are very deformed, it's possible that the bosses are failed (or successful) abortions of Isaac's mother's other pregnancies.

• Other bosses seem to be mutated animals/insects, such as Chub and Larry Jr. How they became this way is unknown.

  

• The Health Bar at the top of the screen for each boss (excluding Mask of Infamy) has an angry face to the left of it. This is a reference to the Newgrounds site, where a character called Mr. Angry Face is known for that symbol.

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