The Binding of Isaac Wiki

Best Friends Forever

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A heart with an arrow pierced through it and labeled with the letters BFF.


Makes all Familiars grow larger and gives a boost to their effect. Familiars that fire shots of any kind will do more damage. This includes any Familiars you already have.


  • When used in conjuction with Monstro's Lung, Issac's tears also grow larger.
  • Also increases the size of Guppy's Hairball.

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