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Beelzebub, also known as Lord of the Flies, is a transformation that occurs in The Binding of Isaac: Rebirth.
- Turns Isaac into a giant humanoid fly.
- Most enemy flies will automatically become blue flies.
At least three of these items must be collected for Isaac to transform.
- ???'s Only Friend
- Best Bud
- Big Fan
- Distant Admiration
- Forever Alone
- Friend Zone
- Halo Of Flies
- Hive Mind
- Jar of Flies
- Lost Fly
- Obsessed Fan
- Papa Fly
- Smart Fly
- The Mulligan
- The name of the transformation is named after the demon who is known as the "lord of the flies" or "chief of the devils".
- Beelzebub is a demonic fly and one of the seven princes of Hell.
- Beelzebub is also a name for the devil.