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- For other uses, see Fly (disambiguation).
Attack Flies are red and black flashing flies that will follow Isaac relentlessly until killed. They are commonly found in every chapters appearing in both The Binding of Isaac and the Rebirth remake.
Their only way of damaging Isaac is by contact, and they move rather slowly, making them easy to kill. However, they can be dangerous when found in groups, as they can swarm around Isaac quickly.
Attack Flies turn into regular Black Flies if Isaac has Skatole. They take a small amount of time to convert into Black Flies, so it is possible for Isaac to be damaged if the player is not careful.
These have the exact same behavior as regular attack flies, and move at the same speed. However, they're larger and have more health than regular Attack Flies.
Large Attack Flies are unaffected by Skatole.
- Can be spawned by The Duke of Flies.
- They have multiple chances to spawn from the Shell Game Beggar from the Arcade.