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Isaac becomes stained with blood when he has this item.
When he receives damage, he leaves a trail of Red Creep (blood) behind him, damaging enemies that step on it. Does not affect Flies
Picking up the item also gives the player +5 range stat.
- In Rebirth, occasionally when you obtain this item as Azazel, His eyes do not move while charging or releasing his version of brimstone when he looks towards the screen.
- Lazarus receives this item when he is resurrected (Lazarus II).
- Actual anemia is a condition wherein one lacks either red blood cells or hemoglobin in the blood. Its symptoms are a general feeling of tiredness. One cause of anemia is excessive blood loss, like this item causes.
- This item's icon is only the reversed icon of the Bloody Lust item.