Anemic is a passive item introduced in The Binding of Isaac: Rebirth. It is an inverted drop of blood.


Isaac becomes stained with blood when he has this item.

When he receives damage, he leaves a trail of Red Creep (blood) behind him, damaging enemies that step on it. Does not affect Flies

Picking up the item also gives the player +5 range stat.


  • In Rebirth, occasionally when you obtain this item as Azazel, His eyes do not move while charging or releasing his version of brimstone when he looks towards the screen.
  • Lazarus receives this item when he is resurrected (Lazarus II).
  • Actual anemia is a condition wherein one lacks either red blood cells or hemoglobin in the blood. Its symptoms are a general feeling of tiredness. One cause of anemia is excessive blood loss, like this item causes.
  • This item's icon is only the reversed icon of the Bloody Lust item.

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