Wikia

Achievements are rewarded to the player after completing challenges or reaching certain milestones in The Binding of Isaac. There are a total of 84 achievements in the game; 52 from the main game and a further 32 from the Wrath of the Lamb DLC.

Note that the game saves periodically over time, and also saves when you use the in-game command to exit. For your own sake, make sure to always use the in-game command to exit the game, as opposed to force-quitting, clicking the X, or so on. It may be advisable to exit after a winning run or other major unlock, even if you plan to continue playing, simply as a precaution.

Note: In WOTL, achievements from TBOI sometimes are not unlocked when requirements are met.

List of Achievements

Name	Description	How To Unlock
The Radioactive Spider	Complete The Basement	Defeat the Boss in Basement 2.
Monstro's Tooth	Defeat all bosses in the basement	Defeating all types of boss in The Basement.
The Spelunker	Complete The Caves	Defeat the Boss in Caves 2.
Lil Chubby	Defeat all bosses in the caves	Defeat all types of bosses in Caves.
I Killed Mom!	Kill Mom...	Defeat the boss in The Depths 2.
Loki's Horns	Defeat all bosses in The Depths	Defeat all types of bosses in The Depths.
The Rock	I like to break things...	Destroy 50 stones over multiple playthroughs.
The Bean	You don't wanna know where this bean has been...	Destroy 50 poop over multiple playthroughs.
Mom's Pill Bottle	Mom needs her pills! Donate blood	Use Blood Donation Machines 20 times over multiple playthroughs.
The Gamekid	I lost mine in the Arcade...	Enter different arcades 10 times over multiple playthroughs.
The Common Cold	Dirty needles... eww	Collect 2 of these in one playthrough: Roid Rage, The Virus, and Growth Hormones.
Mr. Mega!	Kids shouldn't play with matches	Destroy 10 X Marks the Spot rocks over multiple playthroughs.
The Book of Sin	Destroy the 7 sins!	Defeat all of The Seven Deadly Sins across multiple playthroughs.
Mom's Contacts	Stay out of mom's things!	Collect Mom's Eye after collecting any other Mom's item in the same playthrough.
The Parasite	Kids shouldn't play with dead things...	Collect two "dead items" (Bob's Rotten Head, Guppy, Max's Head, Tammy's Head) in the same playthrough.
The Necronomicon	Call Death upon all of them!	Use the Death Tarot Card 4 times over multiple playthroughs.
The Halo	Give Mom a taste of her own medicine!	Kill Mom with the Bible in The Depths 2. (Using it will automatically kill her.)
The Bandage	Make a Super Meat Boy!	Kill all four horsemen in one playthrough.
The Shears	I've lost my head one too many times...	Die 100 times.
Maggy's Wig	Collect 7+ container hearts in one play through	Have a maximum HP of 7 in a single playthrough.
Cain's Eyepatch	Collect 50+ pennies in one play through	Have 55 or more pennies on hand at once.
Judas' Fez	Complete the full game	Defeat the boss in The Womb 2.
???	Complete the full game 10 times	Defeat the Boss in The Womb 2 a tenth time.
My Head Hurts...	Defeat Steven.	Defeat the alternate Boss Steven.
I need a hug...	Defeat C.H.A.D..	Defeat the alternate Boss C.H.A.D..
I Have Sticker Fingers...	Defeat Gish.	Defeat the alternate Boss Gish.
The Noose	Complete the full game 2 times	Defeat the Boss in The Womb 2 a second time.
The Nail	Complete the full game 3 times	Defeat the Boss in The Womb 2 a third time.
The Quarter	Complete the full game 4 times	Defeat the Boss in The Womb 2 a fourth time.
The Fetus	Complete the full game 5 times	Defeat the Boss in The Womb 2 a fifth time.
Everything's Terrible	Complete the full game 6 times	Defeat the Boss in The Womb 2 a sixth time.
The Wafer	Complete the full game 7 times	Defeat the Boss in The Womb 2 a seventh time.
Money = Power	Complete the full game 8 times	Defeat the Boss in The Womb 2 an eighth time.
It Lives!	Complete the full game 9 times	Defeat the Boss in The Womb 2 a ninth time.
The Bag	Complete the full game with Cain.	Defeat the Boss in The Womb 2 with Cain.
The Robo-baby	Complete the full game with Judas	Defeat the Boss in The Womb 2 with Judas.
The Cross	Complete the full game with Maggy.	Defeat the Boss in The Womb 2 with Maggy.
The D6	Complete the full game with ???.	Defeat the Boss in The Womb 2 with ???.
Golden God	100% the game	Collecting every item and power in the game. This achievement can be gained by collecting all but one of the items if you have defeated Krampus and found the lump of coal.
Basement Boy	Complete the Basement without taking damage	Complete the Basement without taking any damage (Blood Donation Machines can still be used). Unlocks after defeating a boss, so the rest of current level can be explored later.
Spelunker Boy	Complete the Caves without taking damage	Complete the Caves without taking damage.
Dark Boy	Complete the Depths without taking damage	Complete the Depths without taking damage. (Can't use "We Need To Go Deeper" to bypass Mom.)
Mama's Boy	Complete the Womb without taking damage	Complete the Womb without taking damage. (Works on XL Maps)
Forget Me Now	Complete Sheol with ???	Defeat the boss in Sheol with ??? (Blue Baby).
Eve's Dead Bird	Make 2 deals with the devil in one play through	Make 2 deals with the devil in a single playthrough.
The Bomb Bag	Complete Sheol with Cain	Defeat the boss in Sheol with Cain.
Moms Knife	Complete Sheol with Isaac	Defeat the boss in Sheol with Isaac.
The Monster Manual	Complete Sheol with Judas	Defeat the boss in Sheol with Judas.
The Razor Blade	Complete the womb with Eve	Defeat the boss in The Womb 2 with Eve.
The Guardian Angel	Complete Sheol with Maggy	Defeat the boss in Sheol with Magdalene.
The Demon Baby	Complete Sheol with Eve	Defeat the boss in Sheol with Eve.
A Gift From Krampus	Find Krampus in Satans room for a gift!	Defeat Krampus in Devil room.
Achievements added in Wrath of the Lamb
Samson	Kill mom but pass on 2 treasure room items.	Pass 2 treasure rooms and defeat Mom.
Blood Lust	Kill moms heart with Samson.	Defeat Mom's Heart or It Lives in The Womb 2 with Samson.
Blood Rights	Kill Satan with Samson	Defeat Satan in Sheol with Samson.
The D20	Complete the final chapter with Isaac.	Defeat Isaac in the Cathedral with Isaac.
The Cross	Complete the final chapter with Maggy.	Defeat Isaac in the Cathedral with Magdalene.
Abel	Complete the final chapter with Cain.	Defeat Isaac in the Cathedral with Cain.
The Curved Horn	Complete the final chapter with Judas.	Defeat Isaac in the Cathedral with Judas.
The Sacrificial Knife	Complete the final chapter with Eve.	Defeat Isaac in the Cathedral with Eve.
The Rainbow Baby	Complete the final chapter with ???.	Defeat Isaac in the Cathedral with ???.
The Bloody Penny	Complete the final chapter with Samson.	Defeat Isaac in the Cathedral with Samson.
The Candle	Complete Challenge 1	Complete Challenge 1: Defeat Mom with Curse of Darkness on every floor.
The Lucky Toe	Complete Challenge 2	Complete Challenge 2: Defeat Mom while starting out with bad luck.
The Burnt Penny	Complete Challenge 3	Complete Challenge 3: Defeat Mom with Curse of the Labyrinth on every floor.
Guppys Tail	Complete Challenge 4	Complete Challenge 4: Defeat Mom, starting out with Guppy.
The Fish Head	Complete Challenge 5	Complete Challenge 5: Defeat Mom's Heart or It Lives, starting out with The Mulligan and Infestation.
Mega Fetus	Complete Challenge 6	Complete Challenge 6: Defeat Mom's Heart or It Lives, starting out with Dr. Fetus and the Doctor's Remote.
Super SMB Fan	Complete Challenge 7	Complete Challenge 7: Defeat Mom's Heart or It Lives, starting out with 4 Cubes of Meat.
The Spider Butt	Complete Challenge 8	Complete Challenge 8: Defeat Mom's Heart or It Lives, starting out with Mutant Spider and Spider's Bite.
The Counterfeit Coin	Complete Challenge 9	Complete Challenge 9: Defeat Satan, starting out with the Holy Grail and The Halo.
Dad's Key	???	Kill final boss in The Chest.
Guppy's Hairball	???	Transform Isaac into a Cat. For details, see Guppy.
The Polaroid	???	Complete the Cathedral five times using any character. Completing the Cathedral with the Polaroid will allow you to enter The Chest.
Daddys Love	???	Complete challenge 10.
Platinum God!	100% the game.	Get all items and all secrets (If you have Ghost Baby you will need one less Item. Confirmed)
???s Soul	???	Complete "The Chest" with ??? (Bugged as of 1.4, unlocks when beating "The Chest" with Cain.)
Samsons Lock	???	Complete "The Chest" with Samson (Bugged as of 1.48, unlocks when beating "The Chest" with ???.)
The Left Hand	???	Defeat Ultra Pride.
Eves Bird Foot	???	Complete "The Chest" with Eve (Bugged as of 1.48, unlocks when beating "The Chest" with Samson.)
Judas' Tongue	???	Complete "The Chest" with Judas (Bugged as of 1.48, unlocks when beating "The Chest" with Eve.)
Isaacs Head	???	Complete "The Chest" with Isaac
Maggys Faith	???	Complete "The Chest" with Maggy
Cains Eye	???	Complete "The Chest" with Cain (Bugged as of 1.48, unlocks when beating "The Chest" with Judas.)

Bugs

Please note that several of the Wrath of the Lamb achievements are bugged and can be found even without having them unlocked.
When you defeat the Headless Horseman you may get the achievement for defeating C.H.A.D..
The Sacrificial Knife may be unlocked if you use a Joker Card or "We Need To Go Deeper" on a Womb XL floor to go directly to Sheol and then beat Satan with Eve. (as though you had beaten Isaac.) (Needs confirmation if it works with other characters on a similar situation.)